Développement d’une thérapie ciblée pour le cancer du sein triple négatif

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La Société canadienne du cancer du sein et sa mission de sauver des vies grâce à la recherche sur le cancer du sein sont très importantes ; les chercheurs comme moi sont extrêmement reconnaissants envers tous ceux qui font des dons et soutiennent la Société canadienne du cancer du sein. En tant que l’un des nombreux chercheurs sur le cancer du sein à Calgary, je voulais vous remercier pour le financement fourni par la Société canadienne du cancer du sein qui nous permet de tester de nouveaux concepts dans le cadre de notre quête pour mettre fin au cancer du sein. J’ai l’honneur de vous écrire aujourd’hui pour vous faire part de notre quête d’une nouvelle approche thérapeutique ciblée pour les patientes atteintes d’un cancer du sein triple négatif (CSTN). À l’exception des patientes atteintes d’un cancer du sein avec BRCA positif, il n’existe actuellement aucun traitement ciblé pour cette forme agressive de cancer du sein.

Notre histoire ;
En examinant la littérature pour développer une idée que l’un de nos estimés chercheurs en oncologie médicale avait eue, j’ai trouvé des preuves qu’un gène spécifique du cancer du sein était souvent “désactivé” (ou réduit au silence). Cela a attiré mon attention car je savais qu’un médicament particulier utilisé pour traiter une forme agressive de cancer du cerveau est plus efficace lorsque ce gène est réduit au silence de la même manière, comme je l’ai trouvé dans environ 50 % des cas de cancer du cerveau dans la littérature scientifique. Ma question suivante était donc la suivante : ce traitement a-t-il déjà été testé pour le cancer du sein ? La réponse a été oui ; cependant, il a été utilisé dans des essais cliniques comme traitement potentiel des métastases cérébrales, car il s’agit de l’un des rares médicaments capables de pénétrer les tumeurs dans le cerveau. Qu’ont-ils vu ? Les résultats sont mitigés : certains patients semblent bénéficier d’un avantage, mais de nombreux autres n’en tirent aucun avantage. Il est important de noter que la majorité de ces recherches ont été menées avant que l’on ne découvre que ce traitement était plus efficace chez les patients chez qui le gène spécifique auquel j’ai fait allusion plus tôt était “désactivé”. Notre hypothèse était que ceux qui avaient une réponse avaient très probablement ce gène réduit au silence, et que ce médicament serait plus efficace chez les patients qui ont ce gène réduit au silence. (L’autre aspect important de ce traitement ciblé potentiel est que les essais cliniques antérieurs ont montré que le médicament était bien toléré avec des effets secondaires minimes par rapport aux options thérapeutiques actuelles pour le cancer du sein). Nous étions très enthousiastes, mais nous avions besoin de plus de preuves pour étayer notre hypothèse. Nous avons donc préparé une proposition de projet et l’avons soumise au comité consultatif de notre société locale de lutte contre le cancer du sein pour demander un financement de démarrage.

Nous avons réussi !
Grâce au financement de la Société canadienne du cancer du sein, nous avons pu tester notre hypothèse en laboratoire et obtenir des preuves supplémentaires à l’appui de notre théorie. Super excitant ! Mais où allons-nous maintenant ? Je suis heureux d’annoncer que nous avons pu tirer parti de nos résultats pour obtenir un financement de près d’un million de dollars de la part d’une grande agence canadienne afin d’ouvrir un essai clinique testant cette nouvelle approche thérapeutique chez les patients atteints de cancer du sein. Nous sommes ravis d’ouvrir le procès l’année prochaine en Alberta. Nous espérons que notre essai provincial s’étendra par la suite à un essai pancanadien et qu’il débouchera sur une nouvelle approche de traitement clinique pour les patientes atteintes de cancer du sein.

Je suis impatient de vous fournir des mises à jour supplémentaires à l’avenir !

Une fois de plus, je dois rappeler que rien de tout cela ne serait possible sans le soutien généreux des donateurs et de la Société canadienne du cancer du sein. La recherche est importante !

Sincèrement,
Elizabeth N Kornaga
Chercheur en recherche translationnelle, Tom Baker Cancer Centre, Calgary, Alberta

Soutenez des chercheurs comme Elizabeth Kornaga en envisageant de faire un don à la Société canadienne du cancer du sein. Pour savoir comment vous pouvez aider à financer des recherches qui sauvent des vies, visitez le site bcsc.ca/donnez dès aujourd’hui.

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There are many ways to fundraise – whether you want to create a competition or tournament, fundraise with your team, challenge your colleagues, host a pink party, have a bake sale or cook-off, the idea is to raise more for breast cancer research.

Breast Cancer Canada will empower you with all the tools you need for a successful fundraiser, and if you need more information, contact Dawn Hamilton at: [email protected]  

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How to Sponsor

Thinking about becoming a corporate partner of Breast Cancer Canada? Amazing. work with all types of organizations. We’ll help you deliver results which are measurable. National or local.

A partnership with Breast Cancer Canada is a win-win. It improves employee engagement, boosts morale, fosters a tighter culture. It raises your organization’s profile and demonstrates your support for breast cancer research. To customers. To employees. To suppliers. Most of all – it makes a positive impact for those affected directly by breast cancer.

We’ll raise money for life-saving breast cancer research, together.

Let’s talk about building your program!

Contact Dawn Hamilton today to get started.
Email: [email protected]
Phone: 1-800-567-8767 

To make an online corporate donation, please click here.

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Leave a legacy. Plan for a future gift.

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Support Breast Cancer Canada with a future gift to create a better future for breast cancer patients. Your gift helps to save lives through early detection and improve outcomes with better treatments.

or more information, please contact Natalina Hamilton: [email protected]


LEAVE A GIFT IN YOUR WILL

This is often called a bequest. It’s the simplest way to make a legacy gift. A gift in your will has no effect on your current income and your estate receives a charitable donation tax receipt. Here’s a sample of simple bequest wording : “To pay the sum of $_________ OR _______% of the residue of my estate to Breast Cancer Canada.”


DONATING A LIFE INSURANCE POLICY

Life insurance is a way to provide financial security for your family. If the needs of your family are already taken care of, a life insurance policy is a smart way to donate to charity including tax savings for your estate. Speak to your financial advisors for your personalized advice and learn how a gift of life insurance can work for you. Here’s the top-line on ways of leaving gifts of life insurance:


Bequeath your policy to Breast Cancer Canada for the future:

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Transfer ownership of a paid-up policy to Breast Cancer Canada now:

  • Want to gift us your existing, paid-up policy right now? Make Breast Cancer Canada the beneficiary and owner of your policy. You will receive a donation receipt for the fair market value of the policy. BCC may redeem the policy now, or hold it and receive the face value in the future – however your gift can be put to best use.


Transfer ownership of a policy on which premiums are still owing to BCC now:

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DONATE A TFSA, RRSP, RRIF

Register a significant difference in the lives of those affected by breast cancer. Donate the proceeds of a registered account: Tax-free savings account (TFSA); Registered retirement savings plan (RRSP); Registered retirement income fund (RRIF). It’s a smart way to make a major contribution. Without reducing your current assets. Without subjecting the funds to probate fees. While reducing taxes on your estate through a donation receipt.

Making a gift like this is easy. Designate Breast Cancer Canada as the beneficiary of your registered account.  You benefit from the full use of your account(s) during your lifetime. We receive any remaining funds after your passing.

For more information, contact Natalina Hamilton: [email protected]

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Gifting securities

Donating securities is becoming more popular, and supports Breast Cancer Canada just like cash donations. Gifts of publicly traded securities (stocks, bonds, mutual funds) are an easy, tax-effective way to make a contribution towards life-saving research that helps with early detection, better treatments, and ultimately  Securities can be of any size and given immediately, or you can bequeath them to Breast Cancer Canada in your will. Just like a cash donation, you’ll get a donation tax credit for your gift of securities.

Today, most securities are held electronically and are easily transferred from your brokerage account to our BCC brokerage account. Your Financial Advisor can make all the arrangements.

For more information, contact Natalina Hamilton: [email protected]

Send e-cards in memory or honour

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When you make a monthly contribution to Breast Cancer Canada, you provide stable funding for year-round campaigning and allow us to continue to support research projects across Canada.

 

To join, simply pre-authorize a monthly deduction from your credit card.

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Breast Cancer Canada, National Office
415 Exmouth Street Unit # 101
Sarnia, ON N7T 8A4

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Volunteers are Breast Cancer Canada’s most important resource, and the backbone of our organization. From helping build our PROgress research to helping breast cancer patients, to supporting events, special fundraising projects and administrative tasks, our volunteers are dedicated to making a positive, life-changing impact.

We ensure our volunteers have the best possible experience and apply the Canadian Code for Volunteer Involvement.

You can help us end breast cancer by:

  • Volunteering with one of our fundraising campaigns. Or a BCC signature event
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  • Joining our PROgress research at a local hub
  • Assisting us with virtual office tasks

Learn more about our volunteer driven Regional Hubs.

Regional Hubs are an integral part of Breast Canada Canada. We connect communities and those committed to our mission to make the goal local. Together, we can save lives through advancing breast cancer research, coast to coast.

Connect to learn more about what is happening in your area: [email protected]